High fascin-1 expression in colorectal cancer identifies patients at high risk for early disease recurrence and associated mortality

Abstract Background Fascin is the main actin cross-linker protein that regulates adhesion dynamics and stabilizes cell protrusion, such as filopodia. In human cancer, fascin expression correlates with aggressive clinical features. This study aimed to determine patterns of fascin-1 assessed its prognostic significance in colorectal cancer. Methods One hundred eleven specimens patients primary resectable cancer were examined via immunohistochemistry for fascin-1, results correlated clinicopathological characteristics survival data. Results Fascin-1 staining displayed strong intensity cytoplasm cells endothelial tumor blood vessels. Moderate high was associated progressive anatomic disease extent ( p < 0.001), higher T classification = 0.007), presence lymph node 0.001) distant metastasis 0.002), grade tumors 0.002) vascular invasion 0.001). Patients displaying moderate demonstrated a significantly worse 5-year overall [HR; 3.906, (95%CI) 1.250–12.195] 3-year progression-free 3.448, 1.401–8.475] independent other characteristics. Besides, early-stage only dismal prognosis. Conclusions High an negative factor survival, increasing risk recurrence or death almost by sevenfold. could be potentially utilized identify high-risk prone already disease.